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29. The ability of single-chain surfactants to emulsify an aqueous-based liquid crystal oscillates with odd–even parity of alkyl-chain length  Nisha Varghese,Gauri S. Shetye, Sijie Yang, Stephan Wilkens, Robert P. Smith, Yan-Yeung Luk Journal of Colloid and Interface Science (2013) in press. 

28. Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans Varghese, Nisha; Yang, Sijie; Sejwal, Preeti; Luk, Yan-Yeung Chemical Communications (2013), 49(88), 10418-10420. 

27. Structures and biofilm inhibition activities of brominated furanones for Escherichia coli and Pseudomonas aeruginosa Shetye, Gauri S.; Singh, Nischal; Gao, Xiang; Bandyopadhyay, Debjyoti; Yan, Aixin; Luk, Yan-Yeung MedChemComm (2013), 4(7), 1079-1084. 

26. Enhanced Cell Adhesion and Mature Intracellular Structure Promoted by Squaramide-based RGD Mimics on Bioinert Surfaces  Narasimhan, Sri Kamesh; Sejwal, Preeti; Zhu, Shifa; Luk, Yan-Yeung* In press.

25. Stereochemical Control of Nonamphiphilic Lyotropic Liquid Crystals: Chiral Nematic Phase of Assemblies Separated by Six Nanometers of Aqueous Solvents  Yang, Sijie; Wang, Bing; Cui, Dawei; Kerwood, Deborah; Wilkens, Stephan; Han, Junjie; Luk, Yan-Yeung  Journal of Physical Chemistry B (2013), 117(23), 7133-7143.

24. Emulsion of Aqueous-Based Nonspherical Droplets in Aqueous Solutions by Single-Chain Surfactants: Templated Assembly by Nonamphiphilic Lyotropic Liquid Crystals in Water Nisha Varghese, Gauri S. Shetye, Debjyoti Bandyopadhyay, Nemal Gobalasingham, JinAm Seo, Jo-Han Wang, Barbara Theiler, and Yan-Yeung Luk* Langmuir 2012, 28, 10797−10807.

23. Modification of Proteins with Cyclodextrins Prevents Aggregation and Surface Adsorption and Increases Thermal Stability Deepali Prashar, DaWei Cui, Debjyoti Bandyopadhyay, and Yan-Yeung Luk* Langmuir, 2011, 27, 13091-6.

22. Adamantane-Platinum Conjugate Hosted in β-Cyclodextrin: Enhancing Transport and Cytotoxicity by Noncovalent Modification Deepali Prashar, Yi Shi, Debjyoti Bandyopadhyay, James Dabrowiak and Yan-Yeung Luk* Bioorg. Med. Chem. Lett., 2011, 21, 7421-5.

21. Noncovalent Polymerization of Mesogens Crystallizes Lysozyme: Correlation between Nonamphiphilic Lyotropic Liquid Crystal Phase and Protein Crystal Formation Karen A. Simon, Gauri S. Shetye, Ulrich Englich, Lei Wu, Yan-Yeung Luk* Langmuir, 2011, 27, 10901-6.

20. Stereochemical Effects of Chiral Monolayers on Enhancing the Resistance to Mammalian Cell Adhesion Debjyoti Bandyopadhyay, Deepali Prashar, Yan-Yeung Luk* Chem. Comm. 2011, 47, 6165-7.

19. Anti-Fouling Chemistry of Chiral Monolayers: Enhancing Biofilm Resistance on Racemic Surface Debjyoti Bandyopadhyay, Deepali Prashar and Yan-Yeung Luk* Langmuir, 2011, 27, 6124-31.

18. Water-Driven Ligations Using Cyclic Amino Squarates: A Class of Useful SN1-Like Reactions DaWei Cui, Deepali Prashar, Preeti Sejwal, Yan-Yeung Luk* Chem. Comm. 2011, 47, 1348-1350.

17. Inhibiting microbial biofilm formation by brominated furanones Hou, Shuyu; Duo, Miao; Han, Yongbin; Luk, Yan-Yeung; Ren, Dacheng  Medical Device Materials V, Proceedings of the Materials & Processes for Medical Devices Conference, 2010, 6-10.

16. Noncovalent Polymerization and Assembly in Water Promoted by Thermodynamic Incompatibility Karen A. Simon, Preeti Sejwal, Eric R. Falcone, Erik A. Burton, Sijie Yang, Deepali Prashar, Debjyoti Bandyopadhyay, Sri Kamesh Narasimhan, Nisha Varghese, Nemal S. Gobalasingham, Jason B. Reese, and Yan-Yeung Luk* J. Phys. Chem. B, 2010, 114, 10357-67.

15. Inhibition of Candida albicans Growth by Natural and Synthetic Brominated Furanones Miao Duo, Yan-Yeung Luk*, and Dacheng Ren* Appl. Microbiol. Biotechnol., 2010, 85, 1551-63.

14. Controlling Thread Assemblies of Pharmaceutical Compounds in Liquid Crystal Phase by Using Functionalized Nanotopography Karen A. Simon, Erik A. Burton, Lei Wu and Yan-Yeung Luk* Chem. Mater., 2010, 22, 2434–41.

13. Induced Folding by Chiral Non-Planar Aromatics Sri Kamesh Narasimhan, Deborah J. Kerwood, Lei Wu, Jun Li, Rosina Lombardi, Teresa B. Freedman* and Yan-Yeung Luk* J. Org. Chem., 2009, 74, 7023-33.

12. Selective Immobilization of Peptides Exclusively via N-Terminus Cysteines by Water-Driven Reactions on Surfaces Preeti Sejwal, Sri Kamesh Narasimhan, Deepali Prashar, Debjyoti Bandyopadhyay and Yan-Yeung Luk* J. Org. Chem., 2009, 74, 6843-46.

11. Non-Amphiphilic Assembly in Water: Polymorphic Nature, Thread Structure and Thermodynamic Incompatibility Lei Wu, Jyotsana Lal, Karen A. Simon, Erik A. Burton and Yan-Yeung Luk* J. Am. Chem. Soc., 2009, 131, 7430-7443.

10. Prolonged Control of Patterned Biofilm Formation by Bio-inert Surface Chemistry Shuyu Hou, Erik A. Burton, Ricky Lei Wu, Yan-Yeung Luk* and Dacheng Ren* Chem. Commun., 2009, 10, 1207-1209.

9. Molecular Gradients of Bio-inertness Reveal Mechanistic Difference between Mammalian Cell Adhesion and Bacterial Biofilm Formation Erik A. Burton, Karen A. Simon, Shuyu Hou, Dacheng Ren* and Yan-Yeung Luk* Langmuir, 2009, 25, 1547-1553.

8. Utilizing the high dielectric constant of water: efficient synthesis of amino acid-derivatized cyclobutenones Jun Li, Yongbin Han, Teresa B. Freedman, Shifa Zhu, Deborah J. Kerwood and Yan-Yeung Luk*, Tet. Lett., 2008, 49, 2128-2131.

7. Chiral Molecules with Polyhedral T, O or I Symmetry: Theoretical Solution to A Difficult Problem in Stereochemistry Sri Kamesh Narasimhan, Xiaoying Lu and Yan-Yeung Luk* Chirality 2008, 20, 878-884.

6. Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli Yongbin Han, Shuyu Hou, Karen A. Simon, Dacheng Ren* and Yan-Yeung Luk*, Bioorg. Med. Chem. Lett., 2008, 18, 1006-1010.

5. Water-Driven Chemoselective Reaction of Squarate Derivatives with Amino Acids and Peptides Preeti Sejwal, Yongbin Han, Akshay Shah and Yan-Yeung Luk*, Org. Lett., 2007, 9, 4897-4900.

4. Enhancing Cell Adhesion and Confinement by Gradient Nanotopography Karen A. Simon, Erik A. Burton, Yongbin Han, Jun Li, Anny Huang and Yan-Yeung Luk*, J. Am. Chem. Soc., 2007, 129, 4892-4893.

3. Water-in-Water Emulsions Stabilized by Non-Amphiphilic Interactions: Polymer-Dispersed Lyotropic Liquid Crystals Karen A. Simon, Preeti Sejwal, Ryan B. Gerecht, Yan-Yeung Luk*, Langmuir, 2007, 23, 1453-8.

2. Inhibiting Escherichia Coli Biofilm Formation by Self-Assembled Monolayers of Functional Alkanethiols on Gold Shuyu Hou, Erik A. Burton, Karen A. Simon, Dustin Blodgett, Yan-Yeung Luk* and Dacheng Ren*, Appl. Environ. Microbiol. 2007, 73, 4300-4307.

1. A Biocompatible Surfactant with Folded Hydrophilic Head Group: Enhancing the Stability of Self-Inclusion Complexes of Ferrocenyl in a β-Cyclodextrin Unit by Bond Rigidity Yongbin Han, Kejun Cheng, Karen A. Simon, Yanmei Lan, Preeti Sejwal, Yan-Yeung Luk*, J. Am. Chem. Soc., 2006, 128, 13913-20.

PUBLICATIONS FROM Ph.D. AND POSTDOCTORAL PERIODS (listed in the order of the significance)

1. Luk, Y.-Y. and N.L. Abbott*, Surface-Driven Switching of Liquid Crystals Using Redox-Active Groups on Electrodes. Science, 2003. 301(5633): p. 623-626.

2. Luk, Y.-Y., M. Kato, and M. Mrksich*, Self-Assembled Monolayers of Alkanethiolates Presenting Mannitol Groups Are Inert to Protein Adsorption and Cell Attachment. Langmuir, 2000. 16(24): p. 9604-9608.

3. Luk, Y.-Y., M.L. Tingey, K.A. Dickson, R.T. Raines, and N.L. Abbott*, Imaging the Binding Ability of Proteins Immobilized on Surfaces with Different Orientations by Using Liquid Crystals. J. Am. Chem. Soc., 2004. 126(29): p. 9024-9032.

4. Luk, Y.-Y., C.-H. Jang, L.-L. Cheng, B.A. Israel, and N.L. Abbott*, Influence of lyotropic liquid crystals on the ability of antibodies to bind to surface-immobilized antigens. Chem. Mater., 2005. 17(19): p. 4774-4782.

5. Luk, Y.-Y., M.L. Tingey, D.J. Hall, B.A. Israel, C.J. Murphy, P.J. Bertics, and N.L. Abbott*, Using liquid crystals to amplify protein-receptor interactions: Design of surfaces with nanometer-scale topography that present histidine-tagged protein receptors. Langmuir, 2003. 19(5): p. 1671-1680.

6. Luk, Y.-Y. and N.L. Abbott*, Applications of functional surfactants. Curr. Opin. Colloid Interface Sci., 2002. 7(5,6): p. 267-275.

7. Luk, Y.-Y., S. Campbell, N. Abbot*t, and C. Murphy*, Non-toxic thermotropic liquid crystals for use with mammalian cells. Liq. Cryst., 2004. 31(5): p. 611-621.

8. Luk, Y.-Y., K.-L. Yang, K. Cadwell, and N.L. Abbott, Deciphering the interactions between liquid crystals and chemically functionalized surfaces: Role of hydrogen bonding on orientations of liquid crystals. Surf. Sci., 2004. 570(1-2): p. 43-56.

9. Luk, Y.-Y., N.L. Abbott, J.N. Crain, and F.J. Himpsel*, Dipole-induced structure in aromatic-terminated self-assembled monolayers - A study by near edge x-ray absorption fine structure spectroscopy. J. Chem. Phys., 2004. 120(22): p. 10792-10798.

10. Brake, J.M., M.K. Daschner, Y.-Y. Luk, and N.L. Abbott*, Biomolecular Interactions at Phospholipid-Decorated Surfaces of Liquid Crystals. Science, 2003. 302(5653): p. 2094-2098.

11. Tingey, M.L., Y.-Y. Luk, and N.L. Abbott*, Orientations of liquid crystals on chemically functionalized surfaces that possess gradients in nanometer-scale topography. Adv. Mater., 2002. 14(17): p. 1224-1227.

12. Cheng, L.-L., Y.-Y. Luk, C.J. Murphy, B.A. Israel, and N.L. Abbott*, Compatibility of lyotropic liquid crystals with viruses and mammalian cells that support the replication of viruses. Biomaterials, 2005. 26(34): p. 7173-7182.

13. Tercero Espinoza, L.A., K.R. Schumann, Y.-Y. Luk, B.A. Israel, and N.L. Abbott*, Orientational Behavior of Thermotropic Liquid Crystals on Surfaces Presenting Electrostatically Bound Vesicular Stomatitis Virus. Langmuir, 2004. 20(6): p. 2375-2385.

14. Li, H., Y.-Y. Luk, and M. Mrksich*, Catalytic Asymmetric Dihydroxylation by Gold Colloids Functionalized with Self-Assembled Monolayers. Langmuir, 1999. 15(15): p. 4957-4959.

15. Himpsel, F.J. *, J.L. McChesney, J.N. Crain, A. Kirakosian, V. Perez-Dieste, N.L. Abbott, Y.-Y. Luk, P.F. Nealey, and D.Y. Petrovykh, Stepped Silicon Surfaces as Templates for One-Dimensional Nanostructures. J. Phys. Chem. B, 2004. 108(38): p. 14484-14490.

16. Zheng, F., V. Perez-Dieste, J.L. McChesney, Y.-Y. Luk, N.L. Abbott*, and F.J. Himpsel*, Detection and switching of the oxidation state of Fe in a self-assembled monolayer. Surf. Sci., 2005. 587(3): p. L191-L196.


1. Enhanced Bio-Assays by Using Gradient Nanotopography Inventors: Y.-Y. Luk, K. A. Simons, E. A. Burton, Syracuse University; Filed 2006.

2. A new class of antagonists for intergrin proteins as therapeutic agents Inventors: Y.-Y. Luk, S. Zhu, P. Sejwal, Syracuse University; Submitted 2007.

3. Biocatalytic Materials Built by Water-in-Water Emulsion Inventors: Y.-Y. Luk, Karen A. Simon, Dacheng Ren, Syracuse University; Submitted 2007.

4. Squaraylated Homoserine Lactone: A Class of Non-Halogenated Inhibitor for Biofilm Formation. Syracuse University; Submitted 2012.

5. Method of Covalently Modifying Proteins with Organic Molecules to Prevent Aggregation, Inventors: Y.-Y. Luk, D. Prashar.

6. Bicyclic Furanones with Low toxicity for Microbial Control Inventors: Y.-Y. Luk, D. Prashar, Syracuse University; Submitted 2012.

7. Biosensor based on chemically woven hydrogel. Inventors: Y.-Y. Luk, K. A. Simon, A. Basner, M. P. Weldon, Syracuse University; Submitted 2012.

8. Using Polyol-derivatized Aliphatics to Control Biofilm Formation and Infectious Diseases. Inventors: Y.-Y. Luk, G. S. Shetye, N. Singh Syracuse University; Submitted 2012.

9. Liquid crystals with reduced toxicity, and applications thereof   Inventors: Murphy, Christopher John; Abbott, Nicholas L.; Luk, Yan-Yeung; Campbell, Sean Francis; Cheng, Li-Lin; Jang, Chang-Hyun  PCT Int. Appl. (2005), WO 2005010160 A2 20050203.

10. Metalized substrates with surface topography gradients for forming of liquid crystals Inventors: Abbott, Nicholas L.; Luk, Yan-yeung; Tingey, Matthew Lee   U.S. Pat. Appl. Publ. (2004), US 20040091620 A1 20040513.

11. Liquid crystal switching mechanism   Inventors: Abbott, Nicholas L.; Luk, Yan-yeung  PCT Int. Appl. (2003), WO 2003021339 A2 20030313.

12. Surface modifying composition for biochip preparations  Inventor: Mrksich, Milan; Luk, Yan-Yeung  PCT Int. Appl. (2002), WO 2002030885 A2 20020418.