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Recent News


•    Debjyoti has been interviewed and accepted a postdoctoral position in Professor Christine K. Payne's Laboratory at Georgia Institute of Technology. 4-17-2012


•    SiJie Yang has presented her work, non-microbicidal bicyclic furanones as quorum sensing inhibitors, Stereochemical effects on nonamphiphilic lyotropic liquid crystals in 243rd ACS National Meeting at San Diego, CA. 3-30-3012


•    Debjyoti has been nominated as a candidate for the 2012 Irving S. Sigal Postdoctoral Fellowship. 1-30-2012


•    Congratulations, Debjyoti Bandyopadhyay successfully defended his Ph.D. Thesis. 12-8-2011


•    Luk is invited to be on the Scientific Advisory Board of Orthobond. 11-17-2011


•    Work entitled "Stereochemical effects of chiral monolayers on enhancing the resistance to mammalian cell adhesion" led by Debjyoti Bandyopadhyay was accepted for publication in Chemical Communications. This work describes the different durations of surface confinement of adhered mammalian cells by monolayers comprised of enantiomers and diastereomers of polyol-terminated alkanethiols on gold. Surprisingly, both protein adsorption and mammalian cell adhesion appears to be resisted to different extend by monolayers formed by enantiomeric alkanethiols. Resistance to both protein adsorption and cell adhesion was enhanced by monolayers of a racemic mixture of the enantiomeric alkanethiols. 3-28-2011


•    Conventional types of SN1 reactions are not particularly useful for either synthesis or bioconjugation. Work lead by Dawei Cui discovered a class of SN1 type of water-driven ligations that are useful modifying proteins, and has been published in Chemical Communications. This work has recently been applied to modify proteins with molecules that prevent aggregation and surface adsorption. 3-26-20011


•    Work entitled "Anti-Fouling Chemistry of Chiral Monolayers: Enhancing Biofilm Resistance on Racemic Surface" led by Debjyoti Bandyopadhyay was accepted for publication in Langmuir. This work reveals that chiral polyol monolayers on gold films can distinguish the different stages of biofilm formation. Interestingly, enhanced resistance to biofilm formation was obtained on monolayers formed by a racemic mixture of the enantiomeric alkanethiols. 3-21-2011


•    Work led by SiJie Yang has discovered direct evidences and structural characterization of the thread assemblies of nonamphiphilic lyotropic liquid crystals. 12-1-2010


•    Luk has been invited to participate in the forthcoming 2011 DFG-NSF Research Conference Bioinspired Design and Engineering of Novel Functional Materials scheduled for New York City on March 22-25, 2011.

http://www.biomaterials-2011-dfg-nsf-conference.com

•    Work led by Nisha discovered a way to switch surfactants that normally form only micelles to form vesicles instead. 9-15-2010


•    Debjyoti and Deepali presented their work (two oral presentations and two posters) at the ACS meeting in Boston. 8-28-2010


•    Luk has been invited to give a talk at the Liquid Crystal Gordon Research Conference June 19-24, 2011, Mount Holyoke College, South Hadley, MA. 8-5-2010


•    The work entitled "Noncovalent Polymerization and Assembly in Water Promoted by Thermodynamic Incompatibility" led by Karen, Preeti and Erik was accepted for publication in J. Phys. Chem. B
This work describes how the presence of covalent polymers can promote the noncovalent polymerization of small nonamphipilic molecules to form molecular threads, and the formation of lyotropic liquid crystals by these threads. This work also summarizes the problems of stacking model for this class of liquid crystals, and provides a mechanism (thermodynamic incompatibility and self-association) for entirely water-soluble molecules to demix and phase separate. This work is one of our early steps towards building a new emerging discipline of study – nonamphiphilic colloidal science. 7-17-2010


•    Sri Kamesh Narasimhan gave one talk and presented three posters at the ACS meeting at San Francisco. He reported back, "My keystone talk was well received and according to the professors there shows a lot of promise. The SHL's developed for bacteria work also got a lot of attention. Several professors approached me, including Christian Melanders group and a company representative from Japan. Generally people were interested in SHL's dispersal ability and their relative non-toxicity. The squaramides used for cell adhesion work also provoked some interest. One professor and a scientist from Roche asked me if catalysis can be done with these type of molecules as the amide proton is very acidic." 4-1-2010


•    The work by Karen Simon and others on controlling the thread assemblies of nonamphiphilic molecules in water was accepted for publication in Chemistry of Materials.This work shows a uniform planar alignment of liquid crystal phases containing hydrated molecules on surfaces. This result suggests an assembly structure of thread-like noncovalent polymers rather than of columnar stacks for the so-called chromonic liquid crystals. In addition, the azimuthal direction of the threads shows an odd-even dependence on the number of atoms in the monolayer on the surface. This study presents a powerful method to influence the molecular arrangements in the hydrates of pharmaceutical compounds, of which the activities often depend on the aggregate structure. 3-8-2010


•    Luk group and Amgen have established a collaboration revolving protein modification and characterization. 3-2-2010


•    Karen Simon accepted an offer of Postdoctoral Researcher position in Whitesides Group at Harvard. 2-2-2010
    
•    Erik Burton successfully defended his Ph.D. thesis with praise from one of the tough committee member. 11-24-2009
    
•    Erik Burton successfully builds a new hydrogel-based biosensor for aqueous toxins.


•    Karen Simon gave three talks at the recent colloidal conference - 13th IACIS International Conference on Surface & Colloid Science and 83rd ACS Colloid and Surface Science symposium, New York, NY.
•    Dr. Luk received a phone call from NSF program manager regarding his CAREER award.


•    Research on assembly of large quantity (more than 2.6x10^12) of water-soluble small molecule has been accepted to Journal of The American Chemical Society. This work from Luk group presents a fundamental discovery on molecular interactions and assembly that is different from what has been known for almost 5 thousand years, and suggests a new paradigm in the fabrication of materials and biocatalyst.


•    Research on controlling biofouling has received some highlights.

http://www.sciencedaily.com/releases/2009/03/090319142435.htm

http://www.rsc.org/Publishing/Journals/cb/Volume/2009/4/biofilms_under_control.asp

•    Congratulations. Preeti Sejwal defended her Ph.D. successfully on 31st October 2008.


•    Deepali Prashar has been awarded a grant as a WISE-FPP associate.


•    Preeti Sejwal received an internship and a full time position (Ph.D. entry level) offer by two different sites of Bristol Meyers Squibb.


•    Karen Simon was selected as one of the recipients of a Biomaterials Graduate Fellowship for Spring and Summer 2008.


•    Luk is invited to give a talk at Bristol-Myers Squibb on 1.15.2008.


•    Dr. Lei (Ricky) Wu will arrive on Thanksgiving 2007 to join Luk group as a Postdoctoral researcher.


•    Luk's research and funding is highlighted by Syracuse News:
      http://sunews.syr.edu/story_details.cfm?id=4555

•    Luk attended New York Academy of Sciences Gala Event in New York City with Linda Milosky, Julie Hasenwinkel, Jae Oh, Shiu-Kai Chin, Eric Spina and Nancy Cantor.


•    Preeti's work on Water-Driven Chemoselective Reaction is highlighted by Syracuse Biomaterials Institute (SBI). http://biomaterials.syr.edu/news/luk.html

•    Luk is invited to be a member of newly establish Syracuse Biomaterials Institute (SBI), which has just been officially approved by the Board of Trustee of Syracuse University.
      http://biomaterials.syr.edu/people.html

•    Luk funded Preeti, Karen and Erik for an etiqutte dinner for industry and academic job interviews.


•    Preeti's work on Water-Driven Chemoselective Reactions is accepted for publication in Organic Letters.


•    A Wikipedia entry on "water-in-water emulsion" has been set up public education:
      http://en.wikipedia.org/wiki/Water-in-Water_Emulsions

•    Luk received a phone call from NSF program manager ... *


•    The patent on the work of new integrin antagonist by Preeti, ShiFa and Luk was filed.


•    Luk was awarded a travel grant by Stereochemical Society of Greater New York to present Luk group's research in both theoretical and experimental stereochemistry in the 19th International Symposium on Chirality, July 8-11, San Diego, CA.


•    Preeti Sejwal got an offer of summer internship at Bristol-Myers Squibb.


•    Preeti Sejwal presented her work in the ACS meeting in Chicago.


•    Luk got another CARTI award for using novel hydroshell to detect aqueous toxins.


•    Luk was invited to be on the review panel for NSF Biomaterials Division.


•    Karen and Erik's work on enhancing cell adhesion and confinement by using gradient nanotopography was accepted for publication by J. Am. Chem. Soc.


•    Shuyu Hou, Erik A. Burton, Karen A. Simon's work on controlling the formation of biofilm was accepted for publication by Appl. Environ. Microbiol.


•    Kamesh and Shifa solved a very difficult problem in regioselectivity for the substitution reaction with trioxatriconan.


•    Luk and Kamesh and Xiaoying Lu solved a century-old open problem in theoretical stereochemistry on how to construct chiral molecules with the symmetry point group of T, O or I.


•    Undergraduate Anny Huang won the departmental Birge award for excellence in biochemistry.


•    Karen's work on water-in-water emulsion appeared in Langmuir.


•    Yongbin Han's work on a biocompatible folded surfactant appeared in J. Am. Chem. Soc.